The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment

• Published in: Frontiers in neuroscience Vol. 13; p. 811
• Main Authors: Yan, Nao, Zhang, Jun-Jian
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 06.08.2019; Frontiers Media S.A
• Subjects: Alzheimer's disease; Animal models; Apoptosis; Autophagy; Cell death; Cerebrovascular diseases; Cognitive ability; Dementia; Dementia disorders; Enzymes; Fatty acids; Ferroptosis; Homeostasis; iron dyshomeostasis; Lipid peroxidation; Lipids; Mammals; Metabolism; Neurodegenerative diseases; Neurological diseases; Neuroprotection; Neuroscience; Oxidative stress; Phagocytosis; Sexually transmitted diseases; STD; Traumatic brain injury; vascular cognitive impairment; Vascular dementia; vascular cognitive impairment; ferroptosis; iron dyshomeostasis; lipid peroxidation; oxidative stress
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2019.00811

Vascular cognitive impairment (VCI) is a clinical syndrome that encompasses all forms of cognitive deficits caused by cerebrovascular disease, from mild cognitive impairment to dementia. Vascular dementia, the second most common type of dementia after Alzheimer's disease (AD), accounts for approximately 20% of dementia patients. Ferroptosis is a recently defined iron-dependent form of cell death, which is distinct from apoptosis, necrosis, autophagy, and other forms of cell death. Emerging evidence suggests that ferroptosis has significant implications in neurological diseases such as stroke, traumatic brain injury, and AD. Additionally, ferroptosis inhibition has an obvious neuroprotective effect and ameliorates cognitive impairment in various animal models. Here, we summarize the underlying mechanisms of ferroptosis and review the close relationship between ferroptosis and VCI.