Microfluidic biosensing of circulating tumor cells (CTCs): Recent progress and challenges in efficient diagnosis of cancer

• Published in: Biomedicine & Pharmacotherapy Vol. 134; p. 111153
• Main Authors: Farshchi, Fatemeh, Hasanzadeh, Mohammad
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.02.2021; Elsevier BV
• Subjects: Animals; Biomarkers, Tumor; Biomarkers, Tumor - blood; Biomedical analysis; Biosensing; Biosensing Techniques; Biotechnology; Cancer; Cell Separation; Circulating tumor cells (CTCs); Early Detection of Cancer; Humans; Microfluidic; Microfluidic Analytical Techniques; Nanobiomedicine; Neoplasm Metastasis; Neoplasms; Neoplasms - blood; Neoplasms - diagnosis; Neoplasms - pathology; Neoplastic Cells, Circulating; Neoplastic Cells, Circulating - metabolism; Neoplastic Cells, Circulating - pathology; Predictive Value of Tests; Prognosis; Nanobiomedicine; Biotechnology; Microfluidic; Biomedical analysis; Circulating tumor cells (CTCs); Biosensing; Cancer
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2020.111153

[Display omitted] •Most recent advances and limitations in microfluidic biosensing of CTCs were discussions.•The analytical figures of merit of the developed methods are also evaluated.•Recent improvements of early detection of CTCs by various microfluidic methods were discussed. Cancer metastasis is one of the foremost causes of cancer incidence and fatality in the whole of the world. Circulating tumor cells (CTC) have been confirmed to be among the most significant stimuli of metastasis in recent years and presently are the subject of extensive research aiming to be accurately identified by using biological and physical properties. Among the various studies conducted for isolation, identification, and characterization of CTCs, microfluidic systems have aroused great attention owing to their unique advantages such as low-cost, simplicity, reduction in reagent consumption, miniaturization, fast and precise control. The purpose of this review is to provide an overview of current state of the microfluidic biosensors for the screening of CTCs. Additionally, given the recent progress in this field, future outlook for the development of the microfluidics biosensing is briefly discussed.