A Tick-Borne Langat Virus Mutant That Is Temperature Sensitive and Host Range Restricted in Neuroblastoma Cells and Lacks Neuroinvasiveness for Immunodeficient Mice

• Published in: Journal of Virology Vol. 80; no. 3; pp. 1427 - 1439
• Main Authors: RUMYANTSEV, Alexander A, MURPHY, Brian R, PLETNEV, Alexander G
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.02.2006
• Subjects: Animals; Biological and medical sciences; Brain - virology; Cell Line, Tumor; Cercopithecus aethiops; Encephalitis Viruses, Tick-Borne - genetics; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis Viruses, Tick-Borne - pathogenicity; Encephalitis Viruses, Tick-Borne - physiology; Encephalitis, Tick-Borne - immunology; Encephalitis, Tick-Borne - virology; Fundamental and applied biological sciences. Psychology; Humans; Langat virus; Medical sciences; Mice; Mice, SCID; Microbiology; Miscellaneous; Models, Molecular; Mutagenesis; Mutation; Neuroblastoma - virology; Pathogenesis and Immunity; Phenotype; Protein Conformation; Temperature; Tick-borne encephalitis virus; Tumors; Vaccines, Attenuated - genetics; Vero Cells; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; Viral Vaccines - genetics; Virology; Virulence - genetics; Virus Replication; Nervous system diseases; Microbiology; Rodentia; Malignant tumor; Neuroblastoma; Flavivirus; Virology; Tick borne encephalitis group virus; Virus; Vertebrata; Langat virus; Mammalia; Mouse; Host range; Flaviviridae; Autonomic neuropathy; Temperature sensitive mutation
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/JVI.80.3.1427-1439.2006

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