Selanylimidazopyridine Prevents Lipopolysaccharide-Induced Depressive-Like Behavior in Mice by Targeting Neurotrophins and Inflammatory/Oxidative Mediators

• Published in: Frontiers in neuroscience Vol. 12; p. 486
• Main Authors: Domingues, Micaela, Casaril, Angela M, Birmann, Paloma T, Lourenço, Darling de A, Vieira, Beatriz, Begnini, Karine, Lenardão, Eder J, Collares, Tiago, Seixas, Fabiana K, Savegnago, Lucielli
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 19.07.2018; Frontiers Media S.A
• Subjects: Animals; Antidepressants; Antioxidants; Behavior; Brain-derived neurotrophic factor; Canola; Chronic fatigue syndrome; Cytokines; depression; Diabetes; Drug dosages; Hippocampus; imidazopyridines; Inflammation; Lipid peroxidation; lipopolysaccharide; Lipopolysaccharides; major depressive disorder; Mental depression; Neuroprotection; Neuroscience; Neurosciences; Neurotrophic factors; NF-κB protein; NFkB; Oxidative stress; Prefrontal cortex; Psychotropic drugs; Pyridines; Reactive oxygen species; selenium; Selenium compounds; Brazil; major depressive disorder; selenium; neuroinflammation; NFkB; depression; lipopolysaccharide; mouse models of depressive disorder; imidazopyridines

Inasmuch, as the major depressive disorder (MDD) has been characterized as a heterogeneous disease as the inflammatory processes, neurotrophic factors' dysfunction and oxidative/nitrosative stress are believed to play a vital role in its establishment. Organoselenium compounds stand out due to...