Centromere-Linkage Analysis and Consolidation of the Zebrafish Genetic Map
The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres o...
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Published in | Genetics (Austin) Vol. 142; no. 4; pp. 1277 - 1288 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Genetics Soc America
01.04.1996
Genetics Society of America |
Subjects | |
Online Access | Get full text |
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Summary: | The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0016-6731 1943-2631 1943-2631 |
DOI: | 10.1093/genetics/142.4.1277 |