Centromere-Linkage Analysis and Consolidation of the Zebrafish Genetic Map

The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres o...

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Published inGenetics (Austin) Vol. 142; no. 4; pp. 1277 - 1288
Main Authors Johnson, S. L, Gates, M. A, Johnson, M, Talbot, W. S, Horne, S, Baik, K, Rude, S, Wong, J. R, Postlethwait, J. H
Format Journal Article
LanguageEnglish
Published United States Genetics Soc America 01.04.1996
Genetics Society of America
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Summary:The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads.
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ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/142.4.1277