Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders

A wide variety of studies have identified microglial activation in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activation of peripheral monocytic cells in psychiatric disorders. Considering the ori...

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Published inFrontiers in cellular neuroscience Vol. 10; p. 144
Main Authors Takahashi, Yuta, Yu, Zhiqian, Sakai, Mai, Tomita, Hiroaki
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 03.06.2016
Frontiers Media S.A
Subjects
Antigens
Bipolar Disorder
Blood-Brain Barrier
Brain research
Cytokines
Dendritic cells
Gene expression
Mental Disorders
Microglia
Monocytes
Morphology
Neuroscience
Pathogenesis
Psychiatry
Schizophrenia
Studies
Tumor necrosis factor-TNF
Japan
blood-brain barrier
peripheral biomarker
psychoimmunology
bipolar disorder
monocyte
mental disorder
schizophrenia
microglia
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Summary:A wide variety of studies have identified microglial activation in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activation of peripheral monocytic cells in psychiatric disorders. Considering the origin of microglia, as well as neuropsychoimmune interactions in the context of the pathophysiology of psychiatric disorders, it is reasonable to speculate that microglia interact with peripheral monocytic cells in relevance with the pathogenesis of psychiatric disorders; however, these interactions have drawn little attention. In this review, we summarize findings relevant to activation of microglia and monocytic cells in psychiatric disorders, discuss the potential association between these cell types and disease pathogenesis, and propose perspectives for future research on these processes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Reviewed by: Andrew MacLean, Tulane University, USA; Masahiro Ohgidani, Kyushu University, Japan
Edited by: Takahiro A. Kato, Kyushu University, Japan
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2016.00144