Dynamic Balance of Microglia and Astrocytes Involved in the Remyelinating Effect of Ginkgolide B
Multiple sclerosis (MS) is an inflammatory demyelinating disorder in the central nervous system (CNS), in which remyelination failure results in persistent neurologic impairment. Ginkgolide B (GB), a major terpene lactone and active component of Ginkgo biloba, has neuroprotective effects in several...
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Published in | Frontiers in cellular neuroscience Vol. 13; p. 572 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
08.01.2020
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | Multiple sclerosis (MS) is an inflammatory demyelinating disorder in the central nervous system (CNS), in which remyelination failure results in persistent neurologic impairment. Ginkgolide B (GB), a major terpene lactone and active component of Ginkgo biloba, has neuroprotective effects in several models of neurological diseases. Here, our results show, by using an
cuprizone (CPZ)-induced demyelinating model, administration of GB improved behavior abnormalities, promoted myelin generation, and significantly regulated the dynamic balance of microglia and astrocytes by inhibiting the expression of TLR4, NF-κB and iNOS as well as IL-1β and TNF-α, and up-regulating the expression of Arg-1 and neurotrophic factors. GB treatment also induced the generation of oligodendrocyte precursor cells (OPCs).
cell experiments yielded the results similar to those of the
model. The dynamic balance by decreasing microglia-mediated neuroinflammation and promoting astrocyte-derived neurotrophic factors should contribute to endogenous remyelination. Despite GB treatment may represent a novel strategy for promoting myelin recovery, the precise mechanism of GB targeting microglia and astrocytes remains to be further explored. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Ying Xu, University at Buffalo, United States Reviewed by: Yaping Yan, Shaanxi Normal University, China; Guang-Xian Zhang, Thomas Jefferson University, United States; Zengqiang Yuan, Institute of Basic Medical Sciences (CAMS), China |
ISSN: | 1662-5102 1662-5102 |
DOI: | 10.3389/fncel.2019.00572 |