The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells

• Published in: Journal of Veterinary Medical Science Vol. 70; no. 5; pp. 443 - 448
• Main Authors: Yamada, Y.(Gifu Univ. (Japan)), Sato, R, Kobayashi, S, Hankanga, C, Inanami, O, Kuwabara, M, Momota, Y, Tomizawa, N, Yasuda, J
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.05.2008; Japan Science and Technology Agency
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - veterinary; AGENTES ANTINEOPLASTICOS; Animals; ANTINEOPLASTIC AGENTS; Antineoplastic Agents - pharmacology; BOVIN; bovine lactoferrin; canine mammary gland tumor cell; CATTLE; CELL COUNTING; Cell Line, Tumor; CELLS; CELLULE; CELULAS; CHIEN; CONTEO DE CELULAS; DOGS; Dose-Response Relationship, Drug; G1 arrest; GANADO BOVINO; GLANDE MAMMAIRE; GLANDULAS MAMARIAS; LACTOFERRIN; Lactoferrin - pharmacology; LACTOFERRINAS; LACTOFERRINE; MAMMARY GLANDS; Mammary Neoplasms, Animal - drug therapy; MEDICAMENT CYTOSTATIQUE; NEOPLASMAS; NEOPLASME; NEOPLASMS; NUMERATION CELLULAIRE; PERRO; Time Factors
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.70.443

Lactoferrin has several biological activities, including antitumor activities in some human and animal tumor cells. Clinical trials have been carried out in human medicine based on these effects. However, the antitumor effects of lactoferrin in veterinary medicine remain unknown. In this in vitro study, we demonstrated that co-incubation of canine mammary gland tumor cells (CIPp and CHMp) and bovine lactoferrin induced growth arrest of tumor cells. This growth arrest was associated with induction of G1 arrest. Furthermore, this effect was stronger in tumor cells than in normal cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs.