LIM homeobox protein 5 (Lhx5) is essential for mamillary body development

The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is require...

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Published inFrontiers in neuroanatomy Vol. 9; p. 136
Main Authors Miquelajáuregui, Amaya, Sandoval-Schaefer, Teresa, Martínez-Armenta, Miriam, Pérez-Martínez, Leonor, Cárabez, Alfonso, Zhao, Yangu, Heide, Michael, Alvarez-Bolado, Gonzalo, Varela-Echavarría, Alfredo
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 27.10.2015
Frontiers Media S.A
Subjects
Diencephalon
Embryonic Development
Embryos
Gene expression
Hippocampus
Homeobox
Hypothalamus
Laboratory animals
Memory
Morphogenesis
Mouse
Navigation behavior
Neuroanatomy
Neurons
Neurosciences
Spatial memory
Spinal cord
Thalamus
Thyroid transcription factor 1
transcription factor
Transcription factors
United States > US
Mexico
diencephalon
mouse
transcription factor
embryonic development
hypothalamus
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Summary:The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is required for the generation of the MM and its derived tracts. The MM markers Foxb1, Sim2, and Lhx1 are absent in Lhx5 knock-out mice from early embryonic stages, suggesting abnormal specification of this region. This was supported by the absence of Nkx2.1 and expansion of Shh in the prospective mamillary area. Interestingly, we also found an ectopic domain expressing Lhx2 and Lhx9 along the anterio-posterior hypothalamic axis. Our results suggest that Lhx5 controls early aspects of hypothalamic development by regulating gene expression and cellular specification in the prospective MM.
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Edited by: Luis Puelles, Universidad de Murcia, Spain
Reviewed by: Kenji Shimamura, Kumamoto University, Japan; Nicanor Morales-Delgado, University of Murcia, Spain
Present address: Amaya Miquelajáuregui, UCLA Center for Autism Research and Treatment, 760 Westwood Plaza, Semel Institute, Room A7-461, Los Angeles, CA 90095, USA
ISSN:1662-5129
1662-5129
DOI:10.3389/fnana.2015.00136