The implications of target saturation for the use of drug–target residence time

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Bibliographic Details
Published inNature reviews. Drug discovery Vol. 18; no. 1; p. 84
Main Authors de Witte, Wilhelmus E. A., Danhof, Meindert, van der Graaf, Piet H., de Lange, Elizabeth C. M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2019
Nature Publishing Group
Subjects
631/154/1435
Analysis
Antiretroviral agents
Approximation
Biomedicine
Biotechnology
Cancer Research
correspondence
Drug dosages
Drug targeting
Humans
Medicinal Chemistry
Molecular Medicine
Occupancy
Pharmaceutical Preparations - metabolism
Pharmaceutical research
Pharmacokinetics
Pharmacology/Toxicology
Protein Binding
Simulation
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Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:1474-1776
1474-1784
DOI:10.1038/nrd.2018.234