The Microbiome in Cystic Fibrosis

Observations from studies during the last decade have changed the conventional view of cystic fibrosis (CF) microbiology, which has traditionally focused on a limited suite of opportunistic bacterial pathogens. It is now appreciated that CF airways typically harbor complex microbial communities, and...

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Bibliographic Details
Published inClinics in chest medicine Vol. 37; no. 1; p. 59
Main Authors Huang, Yvonne J, LiPuma, John J
Format Journal Article
LanguageEnglish
Published United States 01.03.2016
Subjects
Bacterial Infections - complications
Bacterial Infections - microbiology
Cystic Fibrosis - complications
Cystic Fibrosis - microbiology
Humans
Lung - microbiology
Microbiota
Culture-independent
Fungi
Virus
Microbiota
Lung
Gut
Bacteria
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Summary:Observations from studies during the last decade have changed the conventional view of cystic fibrosis (CF) microbiology, which has traditionally focused on a limited suite of opportunistic bacterial pathogens. It is now appreciated that CF airways typically harbor complex microbial communities, and that changes in the structure and activity of these communities have a bearing on patient clinical condition and lung disease progression. Recent studies of gut microbiota also suggest that disordered bacterial ecology of the CF gastrointestinal tract is associated with pulmonary outcomes. These new insights may alter future clinical management of CF.
ISSN:1557-8216
DOI:10.1016/j.ccm.2015.10.003