Population-averaged standard template brain atlas for the common marmoset (Callithrix jacchus)

• Published in: NeuroImage (Orlando, Fla.) Vol. 54; no. 4; pp. 2741 - 2749
• Main Authors: Hikishima, K., Quallo, M.M., Komaki, Y., Yamada, M., Kawai, K., Momoshima, S., Okano, H.J., Sasaki, E., Tamaoki, N., Lemon, R.N., Iriki, A., Okano, H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.02.2011; Elsevier Limited
• Subjects: Algorithms; Anatomy, Artistic; Animal cognition; Animals; Atlases as Topic; Brain - anatomy & histology; Callithrix - anatomy & histology; Callithrix jacchus; Common marmoset; Female; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Methods; MRI; Neurosciences; Non-human primates; Population; Standard deviation; Studies; Template; Non-human primates; Common marmoset; Callithrix jacchus; MRI; Template
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2010.10.061

Advanced magnetic resonance (MR) neuroimaging analysis techniques based on voxel-wise statistics, such as voxel-based morphometry (VBM) and functional MRI, are widely applied to cognitive brain research in both human subjects and in non-human primates. Recent developments in imaging have enabled the evaluation of smaller animal models with sufficient spatial resolution. The common marmoset (Callithrix jacchus), a small New World primate species, has been widely used in neuroscience research, to which voxel-wise statistics could be extended with a species-specific brain template. Here, we report, for the first time, a tissue-segmented, population-averaged standard template of the common marmoset brain. This template was created by using anatomical T1-weighted images from 22 adult marmosets with a high-resolution isotropic voxel size of (0.2mm)3 at 7-Tesla and DARTEL algorithm in SPM8. Whole brain templates are available at International Neuroinformatics Japan Node website, http://brainatlas.brain.riken.jp/marmoset/. ►A population-averaged brain template for the common marmoset was created. ►Tissue segmented templates would contribute to precise voxel-wise statistics. ►Templates for male, female and those mixed are available at website.