Endogenous Apelin Is Protective Against Age-Associated Loss of Retinal Ganglion Cells in Mice

• Published in: Frontiers in aging neuroscience Vol. 12; p. 58
• Main Authors: Ishimaru, Yuki, Sumino, Akihide, Shibagaki, Fumiya, Yamamuro, Akiko, Yoshioka, Yasuhiro, Maeda, Sadaaki
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 20.03.2020; Frontiers Media S.A
• Subjects: Age; Aging; apelin; apelin receptor (APJ); cell loss; Degeneration; Electrodes; Gene expression; Immunofluorescence; knock-out; Neuroscience; Pharmaceutical industry; Polymerase chain reaction; Retina; retinal ganglion cell (RGC); Retinal ganglion cells; Rodents; United States > US; Japan; aging; retinal ganglion cell (RGC); apelin; knock-out; apelin receptor (APJ); cell loss

Age-associated loss of retinal ganglion cells (RGCs) causes visual deficits, but there is not yet any therapeutic agent to prevent the loss of these cells. Herein, we report that apelin, an endogenous peptide ligand of APJ receptor, is protective against the age-related loss of RGCs in mice. The mRN...