A Double-Blind, Randomized, Placebo-Controlled Trial of Divalproex Extended-Release in the Treatment of Bipolar Disorder in Children and Adolescents

A double-blind study that involves 150 patients aged 10-17 on the effect of divalproex extended-release in the treatment of bipolar disorder shows that the drug was similar to placebo based on adverse events and that no treatment effect was observed in the drug. The drug is not suitable for treatmen...

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Bibliographic Details
Published inJournal of the American Academy of Child and Adolescent Psychiatry Vol. 48; no. 5; pp. 519 - 532
Main Authors Wagner, Karen Dineen, Redden, Laura, Kowatch, Robert A, Wilens, Timothy E, Segal, Scott, Chang, Kiki, Wozniak, Patricia, Vigna, Namita V, Abi-Saab, Walid, Saltarelli, Mario
Format Journal Article
LanguageEnglish
Published United States Lippincott Williams & Wilkins 01.05.2009
Subjects
Adolescent
Adolescents
Ammonia - blood
Analysis of Variance
Antimanic Agents - administration & dosage
Antimanic Agents - adverse effects
Antimanic Agents - therapeutic use
Bipolar Disorder - drug therapy
Child
Children
Delayed-Action Preparations
Depression (Psychology)
Double-Blind Method
Drug Therapy
Female
Humans
Male
Mental Disorders
Outcomes of Treatment
Patients
Psychiatric Status Rating Scales
Reference Values
Surveys and Questionnaires
Symptoms (Individual Disorders)
Treatment Outcome
Valproic Acid - administration & dosage
Valproic Acid - adverse effects
Valproic Acid - blood
Valproic Acid - therapeutic use
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Summary:A double-blind study that involves 150 patients aged 10-17 on the effect of divalproex extended-release in the treatment of bipolar disorder shows that the drug was similar to placebo based on adverse events and that no treatment effect was observed in the drug. The drug is not suitable for treatment of youths with bipolar I disorder, mixed or manic state.
ISSN:0890-8567
1527-5418
DOI:10.1097/CHI.0b013e31819c55ec