Age-related changes in topological patterns of large-scale brain functional networks during memory encoding and recognition

• Published in: NeuroImage (Orlando, Fla.) Vol. 50; no. 3; pp. 862 - 872
• Main Authors: Wang, Liang, Li, Yanfang, Metzak, Paul, He, Yong, Woodward, Todd S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2010; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Aging - physiology; Brain; Brain - physiology; Brain Mapping; Connectivity; Female; fMRI; Humans; Magnetic Resonance Imaging; Male; Memory; Memory - physiology; Models, Neurological; Network; Network hubs; Neural Pathways - physiology; Neuropsychological Tests; Recognition (Psychology) - physiology; Small-world; Studies; Young Adult; Aging; Small-world; fMRI; Connectivity; Memory; Network
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2010.01.044

In this study we used functional magnetic resonance imaging to investigate age-related changes in large-scale brain functional networks during memory encoding and recognition in 12 younger and 16 older adults. For each participant, functional brain networks were constructed by computing temporal correlation matrices of 90 brain regions and analyzed using graph theoretical approaches. We found the age-related changes mainly in the long-range connections with widespread reductions associated with aging in the fronto-temporal and temporo-parietal regions, and a few age-related increases in the posterior parietal regions. Graph theoretical analysis revealed that the older adults had longer path lengths linking different regions in the functional brain networks as compared to the younger adults. Further analysis indicated that the increases in shortest path length in the networks were combined with the loss of long-range connections. Finally, we showed that for older adults, frontal areas played reduced roles in the network (reduced regional centrality), whereas several default-mode regions played increased roles relative to younger subjects (increased regional centrality). Together, our results suggest that normal aging is associated with disruption of large-scale brain systems during the performance of memory tasks, which provides novel insights into the understanding of age-related decline in multiple cognitive functions.