Depression in adult patients with biotin responsive basal ganglia disease

• Published in: Drug Discoveries & Therapeutics Vol. 10; no. 4; pp. 223 - 225
• Main Authors: Bubshait, Dalal K., Rashid, Asif, Al-Owain, Mohammed A., Sulaiman, Raashda A.
• Format: Journal Article
• Language: English
• Published: Japan International Research and Cooperation Association for Bio & Socio-Sciences Advancement 01.01.2016
• Subjects: Adult; Antidepressive Agents - therapeutic use; Basal ganglia disease; Basal Ganglia Diseases - diagnostic imaging; Basal Ganglia Diseases - drug therapy; Basal Ganglia Diseases - psychology; biotin; Biotin - therapeutic use; Caudate Nucleus - diagnostic imaging; depression; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - psychology; Female; Humans; Magnetic Resonance Imaging; Male; Necrosis; Putamen - diagnostic imaging; Siblings; thiamine; Thiamine - therapeutic use; Vitamin B Complex - therapeutic use
• ISSN: 1881-7831; 1881-784X
• DOI: 10.5582/ddt.2016.01046

Biotin responsive basal ganglia disease (BBGD), is a potentially treatable inherited metabolic disorder which clinically presents as sub-acute encephalopathy in children. Early diagnosis and treatment of this disorder results in good clinical recovery in childhood. However, there is no report in the literature on the long term outcome of these treated patients in adult life. We report two patients with BBGD who were metabolically stable on treatment and developed depression later in life. These cases highlight the association of depression with basal ganglia disorders and demonstrate that depression is the potential long term complication of BBGD.