Immune Regulation of Cancer

Innate and adaptive immune system cells play a major role in regulating the growth of cancer. Although it is commonly thought that an immune response localized to the tumor will inhibit cancer growth, it is clear that some types of inflammation induced in a tumor may also lead to cancer proliferatio...

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Bibliographic Details
Published inJournal of clinical oncology Vol. 28; no. 29; pp. 4531 - 4538
Main Author DISIS, Mary L
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Society of Clinical Oncology 10.10.2010
Subjects
Adaptive Immunity - immunology
Antitumor activity
Biological and medical sciences
Biology of Neoplasia
Bon
Cancer
Cytokines - immunology
Cytokines - metabolism
Dendritic Cells - immunology
Dendritic Cells - metabolism
Humans
Immune response
Immunity, Innate - immunology
Immunoregulation
Immunotherapy - methods
Inflammation
Lymphocytes T
Malignancy
Medical sciences
Microenvironments
Models, Immunological
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - therapy
Parenchyma
Prognosis
Stroma
T-Lymphocytes, Cytotoxic - metabolism
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
Tumors
Immune regulation
Cancerology
Malignant tumor
Cancer
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Summary:Innate and adaptive immune system cells play a major role in regulating the growth of cancer. Although it is commonly thought that an immune response localized to the tumor will inhibit cancer growth, it is clear that some types of inflammation induced in a tumor may also lead to cancer proliferation, invasion, and dissemination. Recent evidence suggests, however, that some patients with cancer can mount an antitumor immune response that has the potential to control or eliminate cancer. Indeed, a so-called "immune response" signature has been described in malignancy that is associated with improved outcomes in several tumor types. Moreover, the presence of specific subsets of T cells, which have the capability to penetrate tumor stroma and infiltrate deep into the parenchyma, identifies patients with an improved prognosis. Immune-based therapies have the potential to modulate the tumor microenvironment by eliciting immune system cells that will initiate acute inflammation that leads to tissue destruction.
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ISSN:0732-183X
1527-7755
DOI:10.1200/JCO.2009.27.2146