Roles of Primary Cilia in the Developing Brain

Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including Sonic hedgehog (Shh) and Wnt signaling. Defects i...

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Published inFrontiers in cellular neuroscience Vol. 13; p. 218
Main Authors Park, Sang Min, Jang, Hee Jin, Lee, Jeong Ho
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 14.05.2019
Frontiers Media S.A
Subjects
autophagy
Cilia
ciliopathy
Defects
FMCD
Genes
Hedgehog protein
Homeostasis
Kidney diseases
Kinases
Ligands
Localization
Molecular modelling
MTOR
Mutation
Neurogenesis
Neuroscience
Organelles
primary cilia
Proteins
Signal transduction
Wnt
Wnt protein
South Korea
FMCD
autophagy
Wnt
primary cilia
MTOR
ciliopathy
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Summary:Essential to development, primary cilia are microtubule-based cellular organelles that protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles in transducing or regulating several signaling pathways, including Sonic hedgehog (Shh) and Wnt signaling. Defects in primary cilia contribute to a group of syndromic disorders known as "ciliopathies" and can adversely affect development of the brain and other essential organs, including the kidneys, eyes, and liver. The molecular mechanisms of how defective primary cilia contribute to neurological defects, however, remain poorly understood. In this mini review, we summarize recent advances in understanding of the interactions between primary cilia and signaling pathways essential to cellular homeostasis and brain development.
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This article was submitted to Cellular Neurophysiology, a section of the journal Frontiers in Cellular Neuroscience
Edited by: Rosanna Parlato, University of Ulm, Germany
Reviewed by: Elisabeth Traiffort, Institut National de la Santé et de la Recherche Médicale (INSERM), France; Esther Stoeckli, University of Zurich, Switzerland
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2019.00218