Variable and Variant Protein Multigene Families in Babesia bovis Persistence

Cattle infected with face a bifurcated fate: Either die of the severe acute infection, or survive and carry for many years a highly persistent but generally asymptomatic infection. In this review, the author describes known and potential contributions of three variable or highly variant multigene-en...

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Bibliographic Details
Published inPathogens (Basel) Vol. 8; no. 2; p. 76
Main Author Allred, David R
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.06.2019
MDPI
Subjects
antigenic variation
Antigens
Asymptomatic infection
Babesia
Babesia bovis
cytoadhesion
Genes
Genomes
immune evasion
immunodominance
Infections
Localization
Parasites
Pathogens
persistent infection
Population
Proteins
Review
Vaccines
Variability
antigenic variation
cytoadhesion
immunodominance
immune evasion
persistent infection
Babesia
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Summary:Cattle infected with face a bifurcated fate: Either die of the severe acute infection, or survive and carry for many years a highly persistent but generally asymptomatic infection. In this review, the author describes known and potential contributions of three variable or highly variant multigene-encoded families of proteins to persistence in the bovine host, and the mechanisms by which variability arises among these families. Ramifications arising from this variability are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens8020076