Thoracic aorta 3D hemodynamics in pediatric and young adult patients with bicuspid aortic valve

• Published in: Journal of magnetic resonance imaging Vol. 42; no. 4; pp. 954 - 963
• Main Authors: Allen, Bradley D., van Ooij, Pim, Barker, Alex J., Carr, Maria, Gabbour, Maya, Schnell, Susanne, Jarvis, Kelly B., Carr, James C., Markl, Michael, Rigsby, Cynthia, Robinson, Joshua D.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: 4D flow MRI; Adolescent; Algorithms; Aorta, Thoracic - pathology; Aorta, Thoracic - physiopathology; Aortic Valve - abnormalities; Aortic Valve - pathology; Aortic Valve - physiopathology; bicuspid aortic valve; Bicuspid Aortic Valve Disease; Blood Flow Velocity; Cardiac-Gated Imaging Techniques - methods; Female; Heart Valve Diseases - pathology; Heart Valve Diseases - physiopathology; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Male; pediatrics; Reproducibility of Results; Sensitivity and Specificity; wall shear stress; Young Adult; 4D flow MRI; bicuspid aortic valve; pediatrics; wall shear stress
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.24847

Background To evaluate the 3D hemodynamics in the thoracic aorta of pediatric and young adult bicuspid aortic valve (BAV) patients. Methods 4D flow MRI was performed in 30 pediatric and young adult BAV patients (age: 13.9 ± 4.4 (range: [3.4, 20.7]) years old, M:F = 17:13) as part of this Institutional Review Board‐approved study. Nomogram‐based aortic root Z‐scores were calculated to assess aortic dilatation and degree of aortic stenosis (AS) severity was assessed on MRI. Data analysis included calculation of time‐averaged systolic 3D wall shear stress (WSSsys) along the entire aorta wall, and regional quantification of maximum and mean WSSsys and peak systolic velocity (velsys) in the ascending aorta (AAo), arch, and descending aorta (DAo). The 4D flow MRI AAo velsys was also compared with echocardiography peak velocity measurements. Results There was a positive correlation with both mean and max AAo WSSsys and peak AAo velsys (mean: r = 0.84, P < 0.001, max: r = 0.94, P < 0.001) and AS (mean: rS = 0.43, P = 0.02, max: rS = 0.70, P < 0.001). AAo peak velocity was significantly higher when measured with echo compared with 4D flow MRI (2.1 ± 0.98 m/s versus 1.27 ± 0.49 m/s, P < 0.001). Conclusion In pediatric and young adult patients with BAV, AS and peak ascending aorta velocity are associated with increased AAo WSS, while aortic dilation, age, and body surface area do not significantly impact AAo hemodynamics. Prospective studies are required to establish the role of WSS as a risk‐stratification tool in these patients. J. Magn. Reson. Imaging 2015;42:954–963.