Neurosecretory cells without neurosecretion: evidence of an independently regulated trait of the cell phenotype
Neurosecretion competence is a fundamental property that enables differentiated neurones and professional neurosecretory cells to store neurotransmitters and hormones in specialized organelles, the synaptic-like vesicles and dense granules, and to release them by regulated exocytosis. In our laborat...
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Published in | The Journal of physiology Vol. 520; no. 1; pp. 43 - 52 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
The Physiological Society
01.10.1999
Blackwell Science Ltd Blackwell Science Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Neurosecretion competence is a fundamental property that enables differentiated neurones and professional neurosecretory cells
to store neurotransmitters and hormones in specialized organelles, the synaptic-like vesicles and dense granules, and to release
them by regulated exocytosis. In our laboratory, the study of rat phaeochromocytoma (PC12) clones that fail to express the
above organelles or any other components involved in neurosecretion, whilst maintaining most of the general markers of the
parental population, has served to demonstrate that this trait is controlled independently from the rest of the phenotype.
The present review focuses on recent advances in elucidating the molecular mechanisms governing neurosecretion competence.
Moreover, the opportunities that such neurosecretion-defective PC12 clones offer for the investigation of new aspects of regulated
exocytosis and the localization of its components are summarized. |
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Bibliography: | Presented at The Journal of Physiology Symposium on Secretion: Mechanisms and Regulation of Exocytosis, Washington DC,17 April 1999. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0022-3751 1469-7793 |
DOI: | 10.1111/j.1469-7793.1999.t01-1-00043.x |