Clinical Relevance of Red Blood Cell Distribution Width (RDW) in Endometrial Cancer: A Retrospective Single-Center Experience from Korea

Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. The medical records of 43...

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Published inCancers Vol. 15; no. 15; p. 3984
Main Authors Eoh, Kyung-Jin, Lee, Tae-Kyung, Nam, Eun-Ji, Kim, Sang-Wun, Kim, Young-Tae
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.08.2023
MDPI
Subjects
Biomarkers
Blood
Cancer
Carcinoma
Cell size
Comparative analysis
Development and progression
Endometrial cancer
endometrial neoplasms
Endometrium
Erythrocytes
Health aspects
Hematology
Hemoglobin
Histology
Inflammation
Lymph nodes
Lymphatic system
Medical examination
Medical prognosis
Medical records
Metastases
Metastasis
mortality
Multivariate analysis
Neutrophils
Oncology, Experimental
Patients
Prognosis
red blood cell distribution
Surgery
Survival analysis
South Korea
United States > US
mortality
red blood cell distribution
endometrial neoplasms
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Abstract Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high ( = 213) and low ( = 218) groups according to the median RDW value (12.8%). The patients with high RDW had significantly advanced-stage ( = 0.00) pelvic lymph node metastasis ( = 0.01) and recurrence ( = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank = 0.03, log-rank = 0.04, respectively). Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.
AbstractList BACKGROUNDRed blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. METHODSThe medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high (n = 213) and low (n = 218) groups according to the median RDW value (12.8%). RESULTSThe patients with high RDW had significantly advanced-stage (p = 0.00) pelvic lymph node metastasis (p = 0.01) and recurrence (p = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank p = 0.03, log-rank p = 0.04, respectively). CONCLUSIONOur results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.
This study aims to investigate the potential use of the red blood cell distribution width (RDW) as a biomarker for predicting prognosis and recurrence in patients with endometrial cancer. We believe that our study makes a significant contribution to the literature because it presents a retrospective analysis of clinical data from 431 patients diagnosed with endometrial cancer, which was conducted to investigate the association between RDW and survival outcomes. The study found that patients with high RDW values had significantly worse overall survival (OS) and disease-free survival (DFS) compared to those with low RDW values. RDW was also found to be an independent prognostic factor for OS and DFS. Further, we believe that this paper will be of interest to the readership of this journal because the study identifies a simple and cost-effective biomarker that can aid in the prognostic evaluation of patients with endometrial cancer. Background: Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. Methods: The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high (n = 213) and low (n = 218) groups according to the median RDW value (12.8%). Results: The patients with high RDW had significantly advanced-stage (p = 0.00) pelvic lymph node metastasis (p = 0.01) and recurrence (p = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank p = 0.03, log-rank p = 0.04, respectively). Conclusion: Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.
Background: Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. Methods: The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high (n = 213) and low (n = 218) groups according to the median RDW value (12.8%). Results: The patients with high RDW had significantly advanced-stage (p = 0.00) pelvic lymph node metastasis (p = 0.01) and recurrence (p = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank p = 0.03, log-rank p = 0.04, respectively). Conclusion: Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.
Simple SummaryThis study aims to investigate the potential use of the red blood cell distribution width (RDW) as a biomarker for predicting prognosis and recurrence in patients with endometrial cancer. We believe that our study makes a significant contribution to the literature because it presents a retrospective analysis of clinical data from 431 patients diagnosed with endometrial cancer, which was conducted to investigate the association between RDW and survival outcomes. The study found that patients with high RDW values had significantly worse overall survival (OS) and disease-free survival (DFS) compared to those with low RDW values. RDW was also found to be an independent prognostic factor for OS and DFS. Further, we believe that this paper will be of interest to the readership of this journal because the study identifies a simple and cost-effective biomarker that can aid in the prognostic evaluation of patients with endometrial cancer.AbstractBackground: Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. Methods: The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high (n = 213) and low (n = 218) groups according to the median RDW value (12.8%). Results: The patients with high RDW had significantly advanced-stage (p = 0.00) pelvic lymph node metastasis (p = 0.01) and recurrence (p = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank p = 0.03, log-rank p = 0.04, respectively). Conclusion: Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.
This study aims to investigate the potential use of the red blood cell distribution width (RDW) as a biomarker for predicting prognosis and recurrence in patients with endometrial cancer. We believe that our study makes a significant contribution to the literature because it presents a retrospective analysis of clinical data from 431 patients diagnosed with endometrial cancer, which was conducted to investigate the association between RDW and survival outcomes. The study found that patients with high RDW values had significantly worse overall survival (OS) and disease-free survival (DFS) compared to those with low RDW values. RDW was also found to be an independent prognostic factor for OS and DFS. Further, we believe that this paper will be of interest to the readership of this journal because the study identifies a simple and cost-effective biomarker that can aid in the prognostic evaluation of patients with endometrial cancer.
Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high ( = 213) and low ( = 218) groups according to the median RDW value (12.8%). The patients with high RDW had significantly advanced-stage ( = 0.00) pelvic lymph node metastasis ( = 0.01) and recurrence ( = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank = 0.03, log-rank = 0.04, respectively). Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.
Audience Academic
Author Eoh, Kyung-Jin
Kim, Young-Tae
Kim, Sang-Wun
Nam, Eun-Ji
Lee, Tae-Kyung
AuthorAffiliation 1 Department of Obstetrics and Gynecology, Yongin Severance Hospital, College of Medicine, Yonsei University, Yongin 16995, Republic of Korea; kjeoh2030@yuhs.ac
2 Department of Obstetrics and Gynecology, College of Medicine, Inha University, Incheon 22332, Republic of Korea; gooddoc0901@gmail.com
3 Department of Obstetrics and Gynecology, Institute of Women’s Medical Life Science, Severance Hospital, College of Medicine, Yonsei University, Seoul 06273, Republic of Korea; nahmej6@yuhs.ac (E.-J.N.); san1@yuhs.ac (S.-W.K.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37568799$$D View this record in MEDLINE/PubMed
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Issue 15
Keywords mortality
red blood cell distribution
endometrial neoplasms
Language English
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Snippet Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed...
Background: Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This...
This study aims to investigate the potential use of the red blood cell distribution width (RDW) as a biomarker for predicting prognosis and recurrence in...
Simple SummaryThis study aims to investigate the potential use of the red blood cell distribution width (RDW) as a biomarker for predicting prognosis and...
BACKGROUNDRed blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This...
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SourceType Open Website
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Aggregation Database
Index Database
StartPage 3984
SubjectTerms Biomarkers
Blood
Cancer
Carcinoma
Cell size
Comparative analysis
Development and progression
Endometrial cancer
endometrial neoplasms
Endometrium
Erythrocytes
Health aspects
Hematology
Hemoglobin
Histology
Inflammation
Lymph nodes
Lymphatic system
Medical examination
Medical prognosis
Medical records
Metastases
Metastasis
mortality
Multivariate analysis
Neutrophils
Oncology, Experimental
Patients
Prognosis
red blood cell distribution
Surgery
Survival analysis
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Title Clinical Relevance of Red Blood Cell Distribution Width (RDW) in Endometrial Cancer: A Retrospective Single-Center Experience from Korea
URI https://www.ncbi.nlm.nih.gov/pubmed/37568799
https://www.proquest.com/docview/2848972908/abstract/
https://search.proquest.com/docview/2850318679
https://pubmed.ncbi.nlm.nih.gov/PMC10417026
https://doaj.org/article/56c06cc0e0e443b5a981da1d633c17c9
Volume 15
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