Clinical Relevance of Red Blood Cell Distribution Width (RDW) in Endometrial Cancer: A Retrospective Single-Center Experience from Korea

• Published in: Cancers Vol. 15; no. 15; p. 3984
• Main Authors: Eoh, Kyung-Jin, Lee, Tae-Kyung, Nam, Eun-Ji, Kim, Sang-Wun, Kim, Young-Tae
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2023; MDPI
• Subjects: Biomarkers; Blood; Cancer; Carcinoma; Cell size; Comparative analysis; Development and progression; Endometrial cancer; endometrial neoplasms; Endometrium; Erythrocytes; Health aspects; Hematology; Hemoglobin; Histology; Inflammation; Lymph nodes; Lymphatic system; Medical examination; Medical prognosis; Medical records; Metastases; Metastasis; mortality; Multivariate analysis; Neutrophils; Oncology, Experimental; Patients; Prognosis; red blood cell distribution; Surgery; Survival analysis; South Korea; United States > US; mortality; red blood cell distribution; endometrial neoplasms
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15153984

Red blood cell distribution width (RDW) is a standard parameter of complete blood count and indicates the variability in red blood cell size. This study aimed to determine whether preoperative RDW can be used to predict the recurrence and prognosis of endometrial carcinoma. The medical records of 431 patients diagnosed with endometrial carcinoma were retrospectively reviewed between May 2006 and June 2018. In addition to RDW, the clinicopathological factors, survival curves, and prognoses of the patients with endometrial carcinoma were compared between the high ( = 213) and low ( = 218) groups according to the median RDW value (12.8%). The patients with high RDW had significantly advanced-stage ( = 0.00) pelvic lymph node metastasis ( = 0.01) and recurrence ( = 0.01) compared to those in the low-RDW group. In univariate analysis with DFS as the endpoint, surgical stage, type II histology, grade, RDW, and lymph node metastasis were independently associated with survival. Patients with high RDW values had significantly shorter disease-free survival and overall survival than those with low RDW values (log-rank = 0.03, log-rank = 0.04, respectively). Our results demonstrate that RDW is a simple and convenient indicator of endometrial carcinoma recurrence. Prospective studies are needed to validate the findings of the current study.