Dengue Antibody and Zika: Friend or Foe?

• Published in: Trends in immunology Vol. 37; no. 10; pp. 635 - 636
• Main Author: Durbin, Anna P
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2016; Elsevier Limited
• Subjects: Allergy and Immunology; Animals; Antibodies, Viral - metabolism; Antibody-Dependent Enhancement; antibody-dependent enhancement of infection; Culicidae - immunology; Dengue - epidemiology; Dengue - immunology; Dengue fever; dengue virus; Dengue Virus - immunology; Disease Outbreaks; Flavivirus; Humans; Illnesses; Immunoglobulins; Infections; Microcephaly; North America - epidemiology; South America - epidemiology; West Nile virus; Zika virus; Zika Virus - immunology; Zika Virus Infection - epidemiology; Zika Virus Infection - immunology; Zika Virus Infection - transmission; Southeast Asia; antibody-dependent enhancement of infection; Zika virus; dengue virus

Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on...