Dengue Antibody and Zika: Friend or Foe?

Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on...

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Bibliographic Details
Published inTrends in immunology Vol. 37; no. 10; pp. 635 - 636
Main Author Durbin, Anna P
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2016
Elsevier Limited
Subjects
Allergy and Immunology
Animals
Antibodies, Viral - metabolism
Antibody-Dependent Enhancement
antibody-dependent enhancement of infection
Culicidae - immunology
Dengue - epidemiology
Dengue - immunology
Dengue fever
dengue virus
Dengue Virus - immunology
Disease Outbreaks
Flavivirus
Humans
Illnesses
Immunoglobulins
Infections
Microcephaly
North America - epidemiology
South America - epidemiology
West Nile virus
Zika virus
Zika Virus - immunology
Zika Virus Infection - epidemiology
Zika Virus Infection - immunology
Zika Virus Infection - transmission
Southeast Asia
antibody-dependent enhancement of infection
Zika virus
dengue virus
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Summary:Zika virus is a mosquito-borne Flavivirus related to dengue that is rapidly spreading through the Americas. This outbreak is occurring in dengue-endemic areas where the population has acquired antibodies to dengue. Recent studies reveal that preexisting dengue antibodies may have opposite effects on Zika infection, transmission, and clinical outcome. Discerning these effects is critical to a better understanding of Zika pathogenesis and the prevention of future outbreaks.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2016.08.006