Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia c...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 292; no. 38; pp. 15588 - 15597
Main Authors Hu, Jinchuan, Selby, Christopher P., Adar, Sheera, Adebali, Ogun, Sancar, Aziz
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 22.09.2017
American Society for Biochemistry and Molecular Biology
Subjects
carcinogenesis
chemotherapy
Chromosome Mapping - methods
damage mapping
damage recognition
DNA Damage
DNA Repair - genetics
Escherichia coli - genetics
Humans
kinetic proofreading
Minireviews
repair mapping
repair mapping
carcinogenesis
damage recognition
damage mapping
chemotherapy
kinetic proofreading
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Summary:Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.
Bibliography:Edited by Ronald C. Wek
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R117.807453