Retroperitoneal Bulky Histiocytic Sarcoma Successfully Treated with Induction Chemotherapy Followed by Curative Surgery

• Published in: Internal Medicine Vol. 56; no. 20; pp. 2765 - 2768
• Main Authors: Oto, Masafumi, Maeda, Akiko, Nose, Taku, Ueda, Yujiro, Uneda, Shima, Inadome, Akito, Oshima, Koichi, Yoshida, Minoru
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2017; Japan Science and Technology Agency
• Subjects: Biopsy; Case Report; Chemotherapy; Computed tomography; Fluorodeoxyglucose F18; histiocytic sarcoma; Histiocytic Sarcoma - diagnosis; Histiocytic Sarcoma - drug therapy; Histiocytic Sarcoma - pathology; Histiocytic Sarcoma - surgery; Humans; Induction Chemotherapy - methods; Internal medicine; Male; Middle Aged; Nephrectomy; Positron emission tomography; Remission Induction; Retroperitoneal Neoplasms - diagnosis; Retroperitoneal Neoplasms - drug therapy; Retroperitoneal Neoplasms - pathology; Retroperitoneal Neoplasms - surgery; Sarcoma; Surgery; Tomography; Tomography, X-Ray Computed; histiocytic sarcoma; chemotherapy; surgery
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.8000-16

Histiocytic sarcoma (HS) is a rare hematopoietic neoplasm. We report a patient with HS treated with induction chemotherapy followed by curative surgery. A 50-year-old man was referred to our hospital because of a retroperitoneal tumor. A computed tomography scan revealed a bulky retroperitoneal mass, infiltrating the surrounding organ. An excisional biopsy confirmed the diagnosis of HS. The tumor shrunk after multidrug chemotherapy. However, positron emission tomography showed uptake of fludeoxyglucose in the residual tumor. He underwent right nephrectomy to remove the tumor. Pathological examination showed complete response. Surgery combined with induction chemotherapy may be an effective way to manage HS.