Protein O-GlcNAcylation and Cardiovascular (Patho)physiology

• Published in: The Journal of biological chemistry Vol. 289; no. 50; pp. 34449 - 34456
• Main Authors: Marsh, Susan A., Collins, Helen E., Chatham, John C.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.12.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylglucosamine - metabolism; Animals; Calcium; Calcium Signaling; Cardiac Hypertrophy; Cardiovascular; Cardiovascular System - cytology; Cardiovascular System - metabolism; Cardiovascular System - pathology; Cardiovascular System - physiopathology; Epigenesis, Genetic; Epigenetics; Glycosylation; Humans; Minireviews; O-Linked N-Acetylglucosamine (O-GlcNAc); Proteins - genetics; Proteins - metabolism; Epigenetics; Calcium; Cardiovascular; O-Linked N-Acetylglucosamine (O-GlcNAc); Cardiac Hypertrophy

Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown...