Protein O-GlcNAcylation and Cardiovascular (Patho)physiology

Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown...

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Published inThe Journal of biological chemistry Vol. 289; no. 50; pp. 34449 - 34456
Main Authors Marsh, Susan A., Collins, Helen E., Chatham, John C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 12.12.2014
American Society for Biochemistry and Molecular Biology
Subjects
Acetylglucosamine - metabolism
Animals
Calcium
Calcium Signaling
Cardiac Hypertrophy
Cardiovascular
Cardiovascular System - cytology
Cardiovascular System - metabolism
Cardiovascular System - pathology
Cardiovascular System - physiopathology
Epigenesis, Genetic
Epigenetics
Glycosylation
Humans
Minireviews
O-Linked N-Acetylglucosamine (O-GlcNAc)
Proteins - genetics
Proteins - metabolism
Epigenetics
Calcium
Cardiovascular
O-Linked N-Acetylglucosamine (O-GlcNAc)
Cardiac Hypertrophy
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Summary:Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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Recipient of the William W. Featheringill Postdoctoral Fellowship from the University of Alabama at Birmingham Comprehensive Cardiovascular Center.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R114.585984