Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance

MGUS affects more than 5% of persons older than 70 years and shortens survival, as compared with age-matched controls. In a long-term study involving more than 1000 patients, those with IgM MGUS had a higher rate of progression to B-cell cancer than those with IgG MGUS.

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Bibliographic Details
Published inThe New England journal of medicine Vol. 378; no. 3; pp. 241 - 249
Main Authors Kyle, Robert A, Larson, Dirk R, Therneau, Terry M, Dispenzieri, Angela, Kumar, Shaji, Cerhan, James R, Rajkumar, S. Vincent
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 18.01.2018
Subjects
Benign monoclonal gammopathy
Immunoglobulin M
Immunoglobulins
Leukemia
Light chains
M protein
Medical disorders
Medical prognosis
Multiple myeloma
Patients
Risk factors
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Summary:MGUS affects more than 5% of persons older than 70 years and shortens survival, as compared with age-matched controls. In a long-term study involving more than 1000 patients, those with IgM MGUS had a higher rate of progression to B-cell cancer than those with IgG MGUS.
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1709974