The Bcl2 family: regulators of the cellular life-or-death switch

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death d...

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Bibliographic Details
Published inNature reviews. Cancer Vol. 2; no. 9; pp. 647 - 656
Main Authors Cory, Suzanne, Adams, Jerry M
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2002
Subjects
Animals
Apoptosis
Caspases - metabolism
Gene mutations
Genetic aspects
Health aspects
Homeostasis
Humans
Models, Molecular
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Non-Hodgkin's lymphomas
Physiological aspects
Protein Conformation
Proto-Oncogene Proteins c-bcl-2 - chemistry
Proto-Oncogene Proteins c-bcl-2 - metabolism
Risk factors
Australia
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Summary:Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective therapeutic approaches.
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ISSN:1474-175X
1474-1768
DOI:10.1038/nrc883