Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea

• Published in: Reproductive toxicology (Elmsford, N.Y.) Vol. 24; no. 1; pp. 114 - 119
• Main Authors: Liu, Hong, Yang, Fan, Li, Zhiping, Chen, Changzhong, Fang, Zhian, Wang, Lihua, Hu, Yonghua, Chen, Dafang
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2007; Elsevier
• Subjects: Adult; Biological and medical sciences; China; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A1 - genetics; Dysmenorrhea; Dysmenorrhea - etiology; Dysmenorrhea - genetics; Embryology: invertebrates and vertebrates. Teratology; Female; Female genital diseases; Fundamental and applied biological sciences. Psychology; Genetic; Genetic Predisposition to Disease; Gynecology. Andrology. Obstetrics; Humans; Logistic Models; Marital Status; Medical sciences; Non tumoral diseases; Odds Ratio; Polymorphism; Polymorphism, Genetic; Prospective Studies; Risk Assessment; Risk Factors; Teratology. Teratogens; Textile Industry; Time Factors; Tobacco smoke pollution; Tobacco Smoke Pollution - adverse effects; Tobacco, tobacco smoking; Toxicology; Women's Health; China; Genetic; Cytochrome P-450 CYP1A1; Tobacco smoke pollution; Dysmenorrhea; Polymorphism; Polymorphism: Genetic: Tobacco smoke pollution; Menstruation disorders; Tobacco smoke; Pollution; Genetic variability; Enzyme; Cytochrome P450; Passive smoking; Cytochrome P-450 CYP1A1: Dysmenorrhea; Genotype; Female genital diseases
• ISSN: 0890-6238; 1873-1708
• DOI: 10.1016/j.reprotox.2007.04.069

This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. This report includes 1645 (1124 no dysmenorrhea, 521 dysmenorrhea) nonsmoking and nondrinking newly wed female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for perceived stress. When stratified by women genotype, the adjusted OR of dysmenorrhea was 1.6 (95%CI = 1.3–2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95%CI = 1.1–2.1) with C/C6235 genotype, compared to nonpassive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 MspI C/C6235 and HincII Ile/Ile462 genotype (OR = 2.6, 95%CI = 1.3–5.2). CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.