Treatment for Mild Chronic Hypertension during Pregnancy

Pregnant women with mild chronic hypertension were randomly assigned to receive medication targeting a normal blood pressure (<140/90 mm Hg) or to receive no treatment unless severe hypertension (>160/105 mm Hg) developed. The incidence of adverse maternal and neonatal outcomes was significant...

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Published inThe New England journal of medicine Vol. 386; no. 19; pp. 1781 - 1792
Main Authors Tita, Alan T., Szychowski, Jeff M., Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna L., Bell, Joseph, Aagaard, Kjersti, Edwards, Rodney K., Gibson, Kelly, Haas, David M., Plante, Lauren, Metz, Torri, Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George R., Hoppe, Kara K., Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle Y., Simhan, Hyagriv N., Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, August, Phyllis, Reddy, Uma M., Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary E., Skupski, Daniel, El-Sayed, Yasser Y., Ogunyemi, Dotum, Galis, Zorina S., Harper, Lorie, Ambalavanan, Namasivayam, Geller, Nancy L., Oparil, Suzanne, Cutter, Gary R., Andrews, William W.
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 12.05.2022
Subjects
Abruptio Placentae - epidemiology
Abruptio Placentae - prevention & control
Age
Antihypertensive Agents - therapeutic use
Antihypertensives
Birth Weight
Blood pressure
Cardiology
Chronic Disease
Complications of Pregnancy
Drug dosages
Edema
Female
Fetal Growth Retardation - epidemiology
Fetal Growth Retardation - prevention & control
Fetuses
Gestational age
Gynecology
Gynecology General
Heart failure
Humans
Hypertension
Hypertension - complications
Hypertension - drug therapy
Hypertension, Pregnancy-Induced - drug therapy
Infant, Newborn
International organizations
Maternal mortality
Neonates
Obstetrics
Patients
Placental abruption
Pre-eclampsia
Pre-Eclampsia - epidemiology
Pre-Eclampsia - prevention & control
Preeclampsia
Pregnancy
Pregnancy Outcome - epidemiology
Premature birth
Premature Birth - epidemiology
Premature Birth - prevention & control
United States > US
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Summary:Pregnant women with mild chronic hypertension were randomly assigned to receive medication targeting a normal blood pressure (<140/90 mm Hg) or to receive no treatment unless severe hypertension (>160/105 mm Hg) developed. The incidence of adverse maternal and neonatal outcomes was significantly lower in the active-treatment group, without an increase in low birth weight.
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A complete list of the investigators in the CHAP Trial Consortium is provided in the Supplementary Appendix, available at NEJM.org.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2201295