Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control

Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accum...

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Bibliographic Details
Published inExperimental & molecular medicine Vol. 52; no. 5; pp. 730 - 737
Main Authors Cho, Hyo Min, Sun, Woong
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.05.2020
Nature Publishing Group UK
Nature Publishing Group
생화학분자생물학회
Subjects
Mitochondria
Neurodegenerative diseases
Quality control
Review
Reviews
Structure-function relationships
생화학
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Summary:Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1226-3613
2092-6413
DOI:10.1038/s12276-020-0434-9