Berberine and Its Study as an Antidiabetic Compound

Diabetes mellitus (DM) is a metabolic disorder that causes hyperglycemia conditions and leads to various chronic complications that causes death. The prevalence of diabetes is predicted to continue to increase, and with the high toxicity levels of current diabetes drugs, the exploration of natural c...

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Published inBiology (Basel, Switzerland) Vol. 12; no. 7; p. 973
Main Authors Utami, Ayudiah Rizki, Maksum, Iman Permana, Deawati, Yusi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.07.2023
MDPI
Subjects
AMPK pathway
antidiabetic compound
Antioxidants
Berberine
Blood glucose
Blood sugar
Cardiovascular system
Diabetes mellitus
Diabetes therapy
Exo-a-sialidase
Glucose tolerance
Hyperglycemia
Inflammation
Insulin
Insulin resistance
Insulin secretion
Kinases
Metabolic disorders
Metformin
Mitochondrial DNA
Mutation
Oxidative stress
Review
Rosiglitazone
Toxicity
Type 2 diabetes
antidiabetic compound
hyperglycemia
diabetes mellitus
AMPK pathway
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Summary:Diabetes mellitus (DM) is a metabolic disorder that causes hyperglycemia conditions and leads to various chronic complications that causes death. The prevalence of diabetes is predicted to continue to increase, and with the high toxicity levels of current diabetes drugs, the exploration of natural compounds as alternative diabetes treatment has been widely carried out, one of which is berberine. Berberine and several other alkaloid compounds, including some of its derivatives, have shown many bioactivities, such as neuraminidase and hepatoprotective activity. Berberine also exhibits antidiabetic activity. As an antidiabetic compound, berberine is known to reduce blood glucose levels, increase insulin secretion, and weaken glucose tolerance and insulin resistance by activating the AMPK pathway. Apart from being an antidiabetic compound, berberine also exhibits various other activities such as being anti-adipogenic, anti-hyperlipidemic, anti-inflammatory, and antioxidant. Many studies have been conducted on berberine, but its exact mechanism still needs to be clarified and requires further investigation. This review will discuss berberine and its mechanism as a natural compound with various activities, mainly as an antidiabetic.
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ISSN:2079-7737
2079-7737
DOI:10.3390/biology12070973