Atherosclerosis: The Emerging Role of Inflammation and the CD40-CD40 Ligand System

Two studies clearly show that disruption of the CD40-CD40 ligand system, a key mediator of cell communication in the immune system, prevents progression of established atherosclerotic lesions to more advanced unstable lesions. This finding provides compelling evidence for the role of chronic inflamm...

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 97; no. 13; pp. 6930 - 6932
Main Author Phipps, Richard P.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 20.06.2000
National Acad Sciences
National Academy of Sciences
The National Academy of Sciences
Subjects
Animals
Antibodies
Arteriosclerosis - etiology
Arteriosclerosis - immunology
Atherosclerosis
B lymphocytes
Cardiovascular disease
CD40 Antigens - immunology
CD40 Ligand
Commentaries
Cytokines
Endothelial cells
Humans
Immune system
Inflammation
Inflammation - immunology
Lesions
Ligands
Membrane Glycoproteins - immunology
Plasma cells
Platelets
Signal Transduction - immunology
T lymphocytes
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Summary:Two studies clearly show that disruption of the CD40-CD40 ligand system, a key mediator of cell communication in the immune system, prevents progression of established atherosclerotic lesions to more advanced unstable lesions. This finding provides compelling evidence for the role of chronic inflammation and elements of the immune response in atherosclerosis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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E-mail: Richard_Phipps@urmc.rochester.edu.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.97.13.6930