Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery

• Published in: British journal of anaesthesia : BJA Vol. 89; no. 2; pp. 242 - 246
• Main Authors: Sayin, M.M., Özatamer, O., Taşöz, R., Kilinç, K., ünal, N.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.08.2002; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Aged; anaesthetics i.v; anaesthetics i.v., propofol; Anesthesia; Anesthesia depending on type of surgery; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - pharmacology; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Coronary Artery Bypass; Coronary Artery Disease - metabolism; Coronary Artery Disease - surgery; heart; Heart - drug effects; heart, coronary artery bypass; Humans; Infusions, Intravenous; lipid; Lipid Peroxidation - drug effects; Lipid Peroxidation - physiology; Medical sciences; metabolism; metabolism, lipid; Middle Aged; Myocardium - metabolism; Neuropharmacology; Pharmacology. Drug treatments; propofol; Propofol - administration & dosage; Propofol - pharmacology; Thoracic and cardiovascular surgery. Cardiopulmonary bypass; anaesthetics i.v., propofol; heart, coronary artery bypass; metabolism, lipid; anaesthetics i.v., propofol; heart, coronary artery bypass; metabolism, lipid; Human; Cardiovascular disease; General anesthesia; Lipids; Myocardial disease; Coronary heart disease; Vascular disease; Cardiopulmonary bypass; Prevention; Reperfusion; General anesthetic; Aortocoronary; Ischemia; Bypass; Surgery; Myocardium; Complication; Propofol; Peroxidation
• ISSN: 0007-0912; 1471-6771
• DOI: 10.1093/bja/aef173

Propofol can scavenge free radicals because it has a chemical structure similar to antioxidants. We examined if free radical scavenging occurs with propofol during CABG operations. We studied 24 patients undergoing CABG surgery for triple vessel disease, randomized into two groups. After induction of anaesthesia with fentanyl 10 μg kg−1 and midazolam 0.1 mg kg−1, patients in the fentanyl group (n=14) received fentanyl infusion 10–30 μg kg−1 h−1 and patients in the propofol group (n=10) received propofol infusion 3–6 mg kg−1 h−1 for maintenance of anaesthesia. Atrial tissue biopsies were taken during cannulation for bypass, 45 min after cross-clamp insertion, 5 min after unclamping, and in the decannulation period. Lipid peroxidation was assessed by measurement of thiobarbituric acid reactive substances (TBARS) in the atrial tissue samples. Lipid peroxidation in the propofol group was less than in the fentanyl group (P<0.05) in all sampling periods. Lipid peroxidation in the fentanyl group increased significantly during cardiopulmonary bypass (CPB) (P<0.05), but no increase was found in the propofol group (P>0.05). In clinical doses, propofol strongly attenuates lipid peroxidation during CABG surgery.