Angiotensin-Related Peptides and Their Role in Pain Regulation

Angiotensin (Ang)-generating system has been confirmed to play an important role in the regulation of fluid balance and blood pressure and is essential for the maintenance of biological functions. Ang-related peptides and their receptors are found throughout the body and exhibit diverse physiologica...

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Published inBiology (Basel, Switzerland) Vol. 12; no. 5; p. 755
Main Authors Nemoto, Wataru, Yamagata, Ryota, Nakagawasai, Osamu, Tan-No, Koichi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.05.2023
MDPI
Subjects
ACE2
Analgesics
Angiotensin
angiotensin (1–7)
Angiotensin II
angiotensin-converting enzyme
Angiotensin-converting enzyme 2
AT1 receptor
AT2 receptor
Blood pressure
Development and progression
Diabetes
Endorphins
Enzymes
Hyperalgesia
Hypertension
Inflammation
Ligands
MAS1 receptor
Pain
Peptides
Peripheral neuropathy
Physiological aspects
Physiology
Review
Spinal cord
Type 2 diabetes
angiotensin (1–7)
neuropathic pain
angiotensin II
AT2 receptor
inflammatory pain
AT1 receptor
MAS1 receptor
angiotensin-converting enzyme
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Summary:Angiotensin (Ang)-generating system has been confirmed to play an important role in the regulation of fluid balance and blood pressure and is essential for the maintenance of biological functions. Ang-related peptides and their receptors are found throughout the body and exhibit diverse physiological effects. Accordingly, elucidating novel physiological roles of Ang-generating system has attracted considerable research attention worldwide. Ang-generating system consists of the classical Ang-converting enzyme (ACE)/Ang II/AT1 or AT2 receptor axis and the ACE2/Ang (1-7)/MAS1 receptor axis, which negatively regulates AT1 receptor-mediated responses. These Ang system components are expressed in various tissues and organs, forming a local Ang-generating system. Recent findings indicate that changes in the expression of Ang system components under pathological conditions are involved in the development of neuropathy, inflammation, and their associated pain. Here, we summarized the effects of changes in the Ang system on pain transmission in various organs and tissues involved in pain development process.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2079-7737
2079-7737
DOI:10.3390/biology12050755