Drug Screening of Hair by Liquid Chromatography-Tandem Mass Spectrometry

• Published in: Journal of analytical toxicology Vol. 32; no. 5; pp. 364 - 372
• Main Authors: Hegstad, S., Khiabani, H.Z., Kristoffersen, L., Kunøe, N., Lobmaier, P.P., Christophersen, A.S.
• Format: Journal Article
• Language: English
• Published: Niles, IL Oxford University Press 01.06.2008; Preston
• Subjects: Analysis; Biological and medical sciences; Chromatography, High Pressure Liquid; Drug addictions; General pharmacology; Hair - chemistry; Humans; Medical sciences; Pharmacology. Drug treatments; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Street Drugs - analysis; Substance Abuse Detection - methods; Tandem Mass Spectrometry - methods; Toxicology; Drug; Validation; Tandem mass spectrometry; Chemical analysis; Coupled method; Psychotropic; HPLC chromatography; Matrix effect; Medical screening; Electrospray; Biological material; Hair (head); Drug of abuse; Quantitative analysis

Hair has become an important matrix for drug analysis, complementary to blood and urine as a matrix. A prolonged detection window makes hair analysis suitable for lhe detection of exposure to illegal and medicinal drugs for periods up to 12 months. In the present study, a liquid chromatography-tande...