No adverse association between exercise exposure and diffuse myocardial fibrosis in male endurance athletes

• Published in: Scientific reports Vol. 14; no. 1; p. 6581
• Main Authors: Andresen, Kristoffer, Klæboe, Lars Gunnar, Lie, Øyvind Haugen, Broch, Kaspar, Kvaslerud, Anette Borger, Bosse, Gerhard, Hopp, Einar, de Lange, Charlotte, Haugaa, Kristina Hermann, Edvardsen, Thor
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/443/592/75/74; 692/4019; Athletes; Blood & organ donations; Cardiology; Cardiovascular disease; Clinical Medicine; Drug dosages; Exercise; Fibrosis; Gadolinium; Heart; Hospitals; Humanities and Social Sciences; Independent sample; Ischemia; Klinisk medicin; Magnetic resonance imaging; Metabolism; Mortality; multidisciplinary; Physical fitness; Physical training; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-57233-5

The potential association between endurance exercise and myocardial fibrosis is controversial. Data on exercise exposure and diffuse myocardial fibrosis in endurance athletes are scarce and conflicting. We aimed to investigate the association between exercise exposure and markers of diffuse myocardial fibrosis by cardiovascular magnetic resonance imaging (CMR) in endurance athletes. We examined 27 healthy adult male competitive endurance athletes aged 41 ± 9 years and 16 healthy controls in a cross sectional study using 3 Tesla CMR including late gadolinium enhancement and T1 mapping. Athletes reported detailed exercise history from 12 years of age. Left ventricular total mass, cellular mass and extracellular mass were higher in athletes than controls (86 vs. 58 g/m 2 , 67 vs. 44 g/m 2 and 19 vs. 13 g/m 2 , all p < 0.01). Extracellular volume (ECV) was lower (21.5% vs. 23.8%, p = 0.03) and native T1 time was shorter (1214 ms vs. 1268 ms, p < 0.01) in the athletes. Increasing exercise dose was independently associated with shorter native T1 time (regression coefficient − 24.1, p < 0.05), but expressed no association with ECV. Our results indicate that diffuse myocardial fibrosis has a low prevalence in healthy male endurance athletes and do not indicate an adverse dose–response relationship between exercise and diffuse myocardial fibrosis in healthy athletes.