In vivo Doppler Ultrasound Quantification of Turbulence Intensity Using A High-Pass Frequency Filter Method

• Published in: Ultrasound in medicine & biology Vol. 36; no. 5; pp. 761 - 771
• Main Authors: Thorne, Meghan L., Rankin, Richard N., Steinman, David A., Holdsworth, David W.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2010; Elsevier
• Subjects: Aged; Algorithms; Biological and medical sciences; Blood Flow Velocity; Butterworth; Cardiovascular system; Carotid artery disease; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - physiopathology; Coherent fluctuation; Doppler ultrasound; Female; High-pass frequency filter; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; in vivo; Incoherent fluctuation; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; MP3 recorder; Radiology; Reproducibility of Results; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Spectral analysis; Turbulence intensity; Ultrasonic investigative techniques; Ultrasonography, Doppler - methods; Carotid artery disease; Coherent fluctuation; Incoherent fluctuation; in vivo; Turbulence intensity; High-pass frequency filter; MP3 recorder; Doppler ultrasound; Butterworth; Spectral analysis; Sonography; Doppler ultrasound study; Turbulence; Method; In vivo; Filter; Carotid; High frequency; Ultrasound; Quantitative analysis; Biomedical engineering
• ISSN: 0301-5629; 1879-291X; 1879-291X
• DOI: 10.1016/j.ultrasmedbio.2010.01.012

The objective of this investigation was to implement a high-pass frequency filter method to analyze Doppler ultrasound velocity waveforms and quantify turbulence intensity (TI) in vivo. Doppler velocity data were analyzed using two techniques, based on either ensemble averaging or high-pass frequency domain filtering of the periodic waveforms. The accuracy and precision of TI measurements were determined with controlled in vitro experiments, using a pulsatile-flow model of a stenosed carotid bifurcation. The high-pass filter technique was also applied in vivo to determine whether this technique could successfully distinguish between pertinent hemodynamic sites within the carotid artery bifurcation. Twenty-five seconds of Doppler audio data were acquired at three sites (common carotid artery [CCA], internal carotid artery [ICA] stenosis and distal ICA) within 10 human carotid arteries, and repeated three times. Doppler velocity data were analyzed using a ninth-order high-pass Butterworth filter with a 12-Hz inflection point. TI measured within the CCA and distal ICA was found to be significantly different ( p < 0.0001) for moderate to nearly occluded carotid artery classifications. Also, TI measured within the distal ICA increased with stenosis severity, with the ability to distinguish between each stenosis class ( p < 0.05). This investigation demonstrated the ability to precisely quantify TI using a conventional Doppler ultrasound machine in human subjects, without interfering with normal clinical protocols. (E-mail: david.holdsworth@imaging.robarts.ca)