Antibiotic resistance in the most unlikeliest of places
According to the CDC, each year at least 2 million people become infected with antibiotic‐resistant bacteria, and of these, at least 23 000 perish (https://www.cdc.gov/drugresistance/index.html). Active sites for predicted enzyme activities were found to be conserved, and 3D modelling reinforced the...
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Published in | Microbial biotechnology Vol. 10; no. 6; pp. 1454 - 1456 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
John Wiley & Sons, Inc
01.11.2017
John Wiley and Sons Inc Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | According to the CDC, each year at least 2 million people become infected with antibiotic‐resistant bacteria, and of these, at least 23 000 perish (https://www.cdc.gov/drugresistance/index.html). Active sites for predicted enzyme activities were found to be conserved, and 3D modelling reinforced the predicted enzyme classifications and identified modifications possibly associated with enhanced thermal stability, such as increased numbers of salt bridges. [...]while the deep sea contains a variety of habitats of growing interest in the search for bioactive secondary metabolites, including aminoglycosides (Tamegai et al., ; Kamjam et al., ), the examination of antibiotic resistance among microbes present at depth had not been previously pursued. [...]given the metal content of the brines, finding a mercury‐detoxifying enzyme, while it is interesting and obviously critical to adaptation, is perhaps not as surprising as that of the genes uncovered in the Microbial Biotechnology article. |
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Bibliography: | Funding information National Science Foundation (1536776), Gulf of Mexico Research Initiative (GOMRI2015‐V‐328), National Oceanic and Atmospheric Association (NA17OAR0110212). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1751-7915 1751-7915 |
DOI: | 10.1111/1751-7915.12868 |