G‐protein‐coupled receptors: past, present and future

The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review p...

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Bibliographic Details
Published inBritish journal of pharmacology Vol. 147; no. S1; pp. S27 - S37
Main Author Hill, Stephen J
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2006
Nature Publishing
Nature Publishing Group
Subjects
Animals
Binding Sites
Biological and medical sciences
British Pharmacological Society 75th Anniversary
cell signalling
desensitization
dimerization
function
General Topics
G‐protein‐coupled receptors
historical perspective
History, 20th Century
History, 21st Century
Humans
ligand binding
Ligands
Medical sciences
Pharmacology. Drug treatments
Radioligand Assay
Receptors, G-Protein-Coupled - drug effects
Receptors, G-Protein-Coupled - history
Receptors, G-Protein-Coupled - physiology
Signal Transduction
British Pharmacological Society 75th Anniversary
historical perspective
Ligand binding
Desensitization
cell signalling
function
Dimerization
In vitro
G-protein-coupled receptors
G protein
Biological receptor
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Summary:The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review provides a brief historical overview of the properties and signalling characteristics of this important family of receptors. British Journal of Pharmacology (2006) 147, S27–S37. doi:10.1038/sj.bjp.0706455
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0706455