Hot spots and future directions of research on the neuroprotective effects of nimodipine

• Published in: Neural regeneration research Vol. 9; no. 21; pp. 1933 - 1938
• Main Author: Li, Runhui
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.11.2014; Medknow Publications & Media Pvt. Ltd; Department of Neurology, Afifliated Central Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: Academic Discussion; Adenosine; Analysis; Blood-brain barrier; Brain research; Cerebrovascular disease; Citation indexes; Cocitation; Diagnosis; Drug therapy; Education; Health aspects; Humanities; Neurosciences; Nimodipine; Pharmacology; R&D; Research & development; Science; Software; Trends; Visualization; 发展趋势; 尼莫地平; 神经保护作用; 科学数据库; 脑血管病; 血脑屏障; 钙离子拮抗剂; 随机对照试验; China; United States > US; Germany; India; Web of Science; visualization; neuroprotection; nimodipine; CiteSpace; scientific mapping; ischemic cerebrovascular disease; nerve regeneration; research fronts; development trends
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.145365

Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tis-sues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the infor-mation visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the ifeld of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.