The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation

• Published in: Intensive care medicine Vol. 43; no. 9; pp. 1352 - 1365
• Main Authors: Jaber, Samir, Bellani, Giacomo, Blanch, Lluis, Demoule, Alexandre, Esteban, Andrés, Gattinoni, Luciano, Guérin, Claude, Hill, Nicholas, Laffey, John G., Maggiore, Salvatore Maurizio, Mancebo, Jordi, Mayo, Paul H., Mosier, Jarrod M., Navalesi, Paolo, Quintel, Michael, Vincent, Jean Louis, Marini, John J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2017; Springer; Springer Nature B.V; Springer Verlag
• Subjects: Anesthesiology; Continuous Positive Airway Pressure - methods; Critical Care Medicine; Critical Illness - therapy; Emergency Medicine; Extracorporeal Membrane Oxygenation - methods; Humans; Intensive; Intensive care; Intensive Care Units; Intubation, Intratracheal - adverse effects; Life Sciences; Mechanical ventilation; Medical colleges; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Noninvasive Ventilation - methods; Oxygen therapy; Pain Medicine; Pediatrics; Pneumology/Respiratory System; Randomized Controlled Trials as Topic; Research Agenda; Respiration, Artificial - methods; Respiratory Insufficiency - physiopathology; Respiratory Insufficiency - therapy; Respiratory system; Ventilation; Ventilator Weaning - methods; Ventilators, Mechanical - adverse effects; France; United Kingdom; Spain; Airways; Acute respiratory failure; Intubation; Non-invasive ventilation; Weaning; Mechanical ventilation
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-017-4896-8

In an important sense, support of the respiratory system has been a defining characteristic of intensive care since its inception. The pace of basic and clinical research in this field has escalated over the past two decades, resulting in palpable improvement at the bedside as measured by both efficacy and outcome. As in all medical research, however, novel ideas built upon observations are continually proposed, tested, and either retained or discarded on the basis of the persuasiveness of the evidence. What follows are concise descriptions of the current standards of management practice in respiratory support, the areas of present-day uncertainty, and our suggested agenda for the near future of research aimed at testing current assumptions, probing uncertainties, and solidifying the foundation on which to base our progress to the next level.