Adverse reactions to N-acetylcysteine

Clinical details of seven patients who suffered adverse reactions to N-acetylcysteine as Parvolex are documented. Skin testing was carried out to diluted Parvolex, and its individual components N-acetylcysteine and ethylenediaminetetra-acetate, in five reacting patients and five patients who had rec...

Full description

Saved in:
Bibliographic Details
Published inHuman & experimental toxicology Vol. 3; no. 5; pp. 393 - 398
Main Authors Bateman, D N, Woodhouse, K W, Rawlins, M D
Format Journal Article
LanguageEnglish
Published England 01.01.1984
Subjects
Acetaminophen - poisoning
Acetylcysteine - administration & dosage
Acetylcysteine - adverse effects
Adolescent
Adult
Aged
Edetic Acid - administration & dosage
Edetic Acid - adverse effects
Female
Humans
Male
Skin Tests
Time Factors
Urticaria - chemically induced
Online AccessGet full text

Cover

More Information
Summary:Clinical details of seven patients who suffered adverse reactions to N-acetylcysteine as Parvolex are documented. Skin testing was carried out to diluted Parvolex, and its individual components N-acetylcysteine and ethylenediaminetetra-acetate, in five reacting patients and five patients who had received Parvolex with no ill-effects. Weal responses to high concentrations (20 mg/ml) of acetylcysteine as Parvolex were significantly greater (p less than 0.02) in reactors. There were no other significant differences between the groups. In two patients who reacted, the effects of intradermal Parvolex could be inhibited by prior therapy with the antihistamine terfenadine. These results suggest a 'pseudo-allergic' rather than an immunological aetiology for adverse reactions to Parvolex.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0144-5952
0960-3271
DOI:10.1177/096032718400300504