Association Between Serum IGF-1 and Diabetes Among U.S. Adults

• Published in: Diabetes care Vol. 33; no. 10; pp. 2257 - 2259
• Main Authors: Teppala, Srinivas, Shankar, Anoop
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.10.2010
• Subjects: adults; Aged; alcoholic beverages; Biological and medical sciences; blood; blood serum; body mass index; cholesterol; diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; education; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; epidemiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; glomerular filtration rate; glucose; Growth hormones; homeostasis; Humans; hypertension; insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Male; Medical sciences; Metabolic diseases; metabolism; Middle Aged; Miscellaneous; National Health and Nutrition Examination Survey; nationalities and ethnic groups; odds ratio; Original Research; Public health. Hygiene; Public health. Hygiene-occupational medicine; Studies; United States; United States; Endocrinopathy; Human; Association; Nutrition; Diabetes mellitus; Adult; Metabolic diseases; Serum; Insulin like growth factor 1; Endocrinology
• ISSN: 0149-5992; 1935-5548; 1935-5548
• DOI: 10.2337/dc10-0770

OBJECTIVE: Serum insulin-like growth factor (IGF)-1 may have a role in the maintenance of glucose homeostasis. We examined the association between serum IGF-1 and diabetes in a representative sample of U.S. adults. RESEARCH DESIGN AND METHODS: Third National Health and Nutrition Examination Survey (NHANES III) participants aged ≥18 years (n = 5,511) were the subjects of the study. The main outcome was the presence of diabetes (n = 387). RESULTS: Lower serum IGF-1 levels were positively associated with diabetes after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, BMI, hypertension, glomerular filtration rate, and serum cholesterol. Compared with quartile 4 of IGF-1 (referent), the odds ratio (OR) of diabetes associated with quartile 1 was OR 2.16 (95% CI 1.24-3.76); P-trend = 0.002. However, the observed association between IGF-1 and diabetes was present only in those <65 years of age (OR = 3.05; P-trend = 0.006) and disappeared in those ≥65 years of age (OR = 0.51; P-trend = 0.18); P-interaction = 0.0056. CONCLUSIONS: Low IGF-1 levels are associated with diabetes among young subjects.