STGC3 inhibits xenograft tumor growth of nasopharyngeal carcinoma cells by altering the expression of proteins associated with apoptosis

STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in n...

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Published inGenetics and molecular biology Vol. 35; no. 1; pp. 18 - 26
Main Authors Qiu, Qing-Chao, Hu, Bo, He, Xiu-Pei, Luo, Qiao, Tang, Guo-Hua, Long, Zhi-Feng, Chen, Zhu-Chu, He, Xiu-Sheng
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Sociedade Brasileira de Genética 01.01.2012
Subjects
BIOCHEMISTRY & MOLECULAR BIOLOGY
CNE2 cell line
GENETICS & HEREDITY
nasopharyngeal carcinoma
nude mouse
STGC3
Tet-on
two-dimensional electrophoresis
CNE2 cell line
Tet-on
nasopharyngeal carcinoma
nude mouse
two-dimensional electrophoresis
STGC3
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Abstract STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE-STGC3/CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xenografts. In addition, Tet/pTRE-STGC3/CNE2+Dox xenografts showed an increase in the percentage of apoptotic cells, a decrease in Bcl-2 protein expression and an increase in Bax protein expression. A proteomic approach was used to assess the protein expression profile associated with STGC3-mediated apoptosis. Western blotting confirmed the differential up-regulation of prohibitin seen in proteomic analysis. These results indicate that overexpression of STGC3 inhibits xenograft growth in nude mice by enhancing apoptotic cell death through altered expression of apoptosis-related proteins such as Bcl-2, Bax and prohibitin. These data contribute to our understanding of the function of STGC3 in human nasopharyngeal carcinoma and provide new clues for investigating other STGC3-associated tumors.
AbstractList STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE- STGC3 /CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE- STGC3 /CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xenografts. In addition, Tet/pTRE- STGC3 /CNE2+Dox xenografts showed an increase in the percentage of apoptotic cells, a decrease in Bcl-2 protein expression and an increase in Bax protein expression. A proteomic approach was used to assess the protein expression profile associated with STGC3-mediated apoptosis. Western blotting confirmed the differential up-regulation of prohibitin seen in proteomic analysis. These results indicate that overexpression of STGC3 inhibits xenograft growth in nude mice by enhancing apoptotic cell death through altered expression of apoptosis-related proteins such as Bcl-2, Bax and prohibitin. These data contribute to our understanding of the function of STGC3 in human nasopharyngeal carcinoma and provide new clues for investigating other STGC3-associated tumors.
STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE-STGC3/CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xenografts. In addition, Tet/pTRE-STGC3/CNE2+Dox xenografts showed an increase in the percentage of apoptotic cells, a decrease in Bcl-2 protein expression and an increase in Bax protein expression. A proteomic approach was used to assess the protein expression profile associated with STGC3-mediated apoptosis. Western blotting confirmed the differential up-regulation of prohibitin seen in proteomic analysis. These results indicate that overexpression of STGC3 inhibits xenograft growth in nude mice by enhancing apoptotic cell death through altered expression of apoptosis-related proteins such as Bcl-2, Bax and prohibitin. These data contribute to our understanding of the function of STGC3 in human nasopharyngeal carcinoma and provide new clues for investigating other STGC3-associated tumors.
Author Long, Zhi-Feng
Tang, Guo-Hua
He, Xiu-Pei
Qiu, Qing-Chao
He, Xiu-Sheng
Hu, Bo
Luo, Qiao
Chen, Zhu-Chu
AuthorAffiliation 5 Department of Otolaryngology, The First People’s Hospital of Yunnan Province, Kunming, China
3 Cancer Research Institute, Central South University, Changsha, China
1 Cancer Research Institute, University of South China, Hengyang, China
4 Hunan Environment-Biological Polytechnic College, Hengyang, China
2 Department of Medicine, Vanderbilt University, Nashville, USA
AuthorAffiliation_xml – name: 4 Hunan Environment-Biological Polytechnic College, Hengyang, China
– name: 3 Cancer Research Institute, Central South University, Changsha, China
– name: 1 Cancer Research Institute, University of South China, Hengyang, China
– name: 2 Department of Medicine, Vanderbilt University, Nashville, USA
– name: 5 Department of Otolaryngology, The First People’s Hospital of Yunnan Province, Kunming, China
– name: The First People's Hospital of Yunnan Province
– name: Vanderbilt University
– name: Central South University
– name: University of Hong Kong
– name: Hunan Environment-Biological Polytechnic College
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22481869$$D View this record in MEDLINE/PubMed
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crossref_primary_10_4238_2012_October_9_9
crossref_primary_10_1111_febs_12838
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Issue 1
Keywords CNE2 cell line
Tet-on
nasopharyngeal carcinoma
nude mouse
two-dimensional electrophoresis
STGC3
Language English
Portuguese
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SSID ssj0027352
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Snippet STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in...
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StartPage 18
SubjectTerms BIOCHEMISTRY & MOLECULAR BIOLOGY
CNE2 cell line
GENETICS & HEREDITY
nasopharyngeal carcinoma
nude mouse
STGC3
Tet-on
two-dimensional electrophoresis
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Title STGC3 inhibits xenograft tumor growth of nasopharyngeal carcinoma cells by altering the expression of proteins associated with apoptosis
URI https://www.ncbi.nlm.nih.gov/pubmed/22481869
https://search.proquest.com/docview/1560126907
https://search.proquest.com/docview/992831335
https://pubmed.ncbi.nlm.nih.gov/PMC3313509
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100002&lng=en&tlng=en
https://doaj.org/article/fb466a0eb9a545e8bbcba8f2b96e1e9a
Volume 35
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