CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various application...
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| Published in | Cell Vol. 168; no. 1-2; pp. 20 - 36 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
12.01.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and we highlight some of the remarkable advancements in basic research, biotechnology, and therapeutics science that these developments have facilitated.
CRISPR-based genome-editing technologies provide powerful tools to study basic biology and may lead to new treatments for human disease. |
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| AbstractList | The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and we highlight some of the remarkable advancements in basic research, biotechnology, and therapeutics science that these developments have facilitated.The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and we highlight some of the remarkable advancements in basic research, biotechnology, and therapeutics science that these developments have facilitated. The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and we highlight some of the remarkable advancements in basic research, biotechnology, and therapeutics science that these developments have facilitated. The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this review we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and some of the remarkable advancements in basic research, biotechnology, and therapeutics development that these developments have facilitated. The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and we highlight some of the remarkable advancements in basic research, biotechnology, and therapeutics science that these developments have facilitated. CRISPR-based genome-editing technologies provide powerful tools to study basic biology and may lead to new treatments for human disease. |
| Author | Badran, Ahmed H. Liu, David R. Komor, Alexis C. |
| AuthorAffiliation | 1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138 3 Broad Institute of MIT and Harvard, Cambridge, MA, 02141 2 Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138 |
| AuthorAffiliation_xml | – name: 1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138 – name: 2 Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138 – name: 3 Broad Institute of MIT and Harvard, Cambridge, MA, 02141 |
| Author_xml | – sequence: 1 givenname: Alexis C. surname: Komor fullname: Komor, Alexis C. organization: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA – sequence: 2 givenname: Ahmed H. surname: Badran fullname: Badran, Ahmed H. organization: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA – sequence: 3 givenname: David R. surname: Liu fullname: Liu, David R. email: drliu@fas.harvard.edu organization: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27866654$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals biotechnology Cells, Cultured CRISPR-Cas Systems Disease - genetics Disease Models, Animal DNA Epigenomics - methods Gene Editing - methods Genetic Therapy genome Humans mammals therapeutics |
| Title | CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes |
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