ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers

• Published in: Cancers Vol. 14; no. 23; p. 5896
• Main Authors: Yang, Yufei, Zhu, Ting, Wang, Xu, Xiong, Fen, Hu, Zhangmin, Qiao, Xuehan, Yuan, Xiao, Wang, Deqiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.11.2022; MDPI
• Subjects: Apoptosis; Cancer; Cancer therapies; Care and treatment; Cell death; Coenzyme A; Ferroptosis; Health aspects; Isoforms; Ligases; Lipid metabolism; Lipid peroxidation; Lipids; Metastases; Molecular modelling; Oxidation; Review; Tumors; China; ACSL4; cancer; ferroptosis; ACSL3

The long-chain fatty acyl CoA synthetase (ACSLs) family of enzymes contributes significantly to lipid metabolism and produces acyl-coenzyme A by catalyzing fatty acid oxidation. The dysregulation of ACSL3 and ACSL4, which belong to the five isoforms of ACSLs, plays a key role in cancer initiation, d...